Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dimethoxyphenylacetic acid → 2-(2,5-dimethoxyphenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dimethoxyphenylacetic acid | HCID 74469 | — |
| 반응물 | 2-amino-4-morpholinophthalazin-1(2H)-one | HCID 70976104 | — |
| 생성물 | 2-(2,5-dimethoxyphenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide | HCID 70976234 | — |
반응 단계
The product of Example 1B and 2-(2,5-dimethoxyphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/D2O) δ 8.32 (d, J=7.8, 1H), 8.03 (d, J=7.8, 1H), 8.01-7.95 (m, 1H), 7.94-7.88 (m, 1H), 6.99 (d, J=3.1, 1H), 6.93 (d, J=8.9, 1H), 6.82 (dd, J=8.9, 3.1, 1H), 3.85-3.81 (m, 4H), 3.76 (s, 3H), 3.72 (s, 3H), 3.59 (s, 2H), 3.14-3.07 (m, 4H); MS (ESI+) M/Z 425 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08859549B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-cd0109ab22744feca8efb7b5fbf03662 |
| 출처 메모 | uspto-grants-2014_10 |