2,5-Dimethoxyphenylacetic acid → 2-(2,5-dimethoxyphenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide

HRID 535592

반응식

HRID 535592 반응식
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[CH3:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:22]=1[CH2:29][C:30](O)=[O:31]>>[CH3:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:22]=1[CH2:29][C:30]([NH:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18])=[O:31]

참가 물질

3

반응물 2

HCID 744692,5-Dimethoxyphenylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

생성물 1

HCID 709762342-(2,5-dimethoxyphenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide

실험 절차

The product of Example 1B and 2-(2,5-dimethoxyphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/D2O) δ 8.32 (d, J=7.8, 1H), 8.03 (d, J=7.8, 1H), 8.01-7.95 (m, 1H), 7.94-7.88 (m, 1H), 6.99 (d, J=3.1, 1H), 6.93 (d, J=8.9, 1H), 6.82 (dd, J=8.9, 3.1, 1H), 3.85-3.81 (m, 4H), 3.76 (s, 3H), 3.72 (s, 3H), 3.59 (s, 2H), 3.14-3.07 (m, 4H); MS (ESI+) M/Z 425 (M+H)+.

출처 및 근거

ORD 기록
ord-cd0109ab22744feca8efb7b5fbf03662
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859549B2

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