Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Benzylpiperazine → 7-(4-Benzyl-piperazin-1-yl)-benzofuran-2-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Benzylpiperazine | HCID 75994 | — |
| 반응물 | Ethyl 7-bromobenzofuran-2-carboxylate | HCID 46738833 | — |
| 생성물 | 7-(4-Benzyl-piperazin-1-yl)-benzofuran-2-carboxylic acid ethyl ester | HCID 59636745 | — |
반응 단계
The compound was prepared according to the procedure disclosed in Example 1a starting from benzylpiperazine (16.1 mL, 92.6 mmol) and 7-bromo-benzofuran-2-carboxylic acid ethyl ester (16.6 g, 61.7 mmol). The product was purified by flash chromatography (SiO2; hexane/EtOAc, gradient 0-50%). Yield: 14 g (63%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08859534B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-c6571e7feed04f2ca443bfcc25b566c3 |
| 출처 메모 | uspto-grants-2014_10 |