1-Benzylpiperazine → 7-(4-Benzyl-piperazin-1-yl)-benzofuran-2-carboxylic acid ethyl ester

HRID 535652

반응식

HRID 535652 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]([O:16][C:17]([C:19]1[O:20][C:21]2[C:27](Br)=[CH:26][CH:25]=[CH:24][C:22]=2[CH:23]=1)=[O:18])[CH3:15]>>[CH2:14]([O:16][C:17]([C:19]1[O:20][C:21]2[C:27]([N:11]3[CH2:12][CH2:13][N:8]([CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH2:9][CH2:10]3)=[CH:26][CH:25]=[CH:24][C:22]=2[CH:23]=1)=[O:18])[CH3:15]

참가 물질

3

반응물 2

HCID 759941-BenzylpiperazineHCID 46738833Ethyl 7-bromobenzofuran-2-carboxylate

생성물 1

HCID 596367457-(4-Benzyl-piperazin-1-yl)-benzofuran-2-carboxylic acid ethyl ester

실험 절차

The compound was prepared according to the procedure disclosed in Example 1a starting from benzylpiperazine (16.1 mL, 92.6 mmol) and 7-bromo-benzofuran-2-carboxylic acid ethyl ester (16.6 g, 61.7 mmol). The product was purified by flash chromatography (SiO2; hexane/EtOAc, gradient 0-50%). Yield: 14 g (63%).

후처리

  1. customThe compound was prepared
  2. customThe product was purified by flash chromatography (SiO2; hexane/EtOAc, gradient 0-50%)

출처 및 근거

ORD 기록
ord-c6571e7feed04f2ca443bfcc25b566c3
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859534B2

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