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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 535668생성일: 2026년 10월 25일

2-(5-Fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonate → 7-(4-(2-(5-Fluoropyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide

https://huagongshe.com/reaction/535668

반응식

참여 물질

역할이름HCID투입량
반응물2-(5-Fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonateHCID 59636712—
반응물N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamideHCID 59636743—
생성물7-(4-(2-(5-Fluoropyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamideHCID 59636731—

반응 단계

The compound was prepared according to the procedure disclosed in Example 46 starting from N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.085 g, 0.31 mmol) (Example 39d) and 2-(5-fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonate (0.092 g, 0.31 mmol). The product was purified by preparative HPLC to give the title compound. Yield: 0.049 g (39%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08859534B2
출처 데이터셋uspto-grants-2014_10
ORD IDord-e2025fd54ad04b05961505495e8f405f
출처 메모uspto-grants-2014_10