4-(chloromethyl)-1-methyl-1H-pyrazole hydrochloride → HCID 86697030, 화합물

HRID 536193노트

반응식

HRID 536193 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][O:17][C:18]3[NH:23][C:22](=[O:24])[N:21]=[CH:20][CH:19]=3)=[N:13][CH:14]=2)=[CH:4][C:3]=1[C:25]([F:28])([F:27])[F:26].Cl.Cl[CH2:31][C:32]1[CH:33]=[N:34][N:35]([CH3:37])[CH:36]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][O:17][C:18]3[CH:19]=[CH:20][N:21]([CH2:31][C:32]4[CH:33]=[N:34][N:35]([CH3:37])[CH:36]=4)[C:22](=[O:24])[N:23]=3)=[N:13][CH:14]=2)=[CH:4][C:3]=1[C:25]([F:26])([F:27])[F:28]

참가 물질

3

반응물 2

HCID 567737394-(chloromethyl)-1-methyl-1H-pyrazole hydrochlorideHCID 67958742HCID 67958742, 화합물

생성물 1

HCID 86697030HCID 86697030, 화합물

실험 절차

The title compound was prepared by a procedure similar to that described for E1 starting from 6-{[2-(5-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-2-pyridinyl)ethyl]oxy}-2(1H)-pyrimidinone and 4-(chloromethyl)-1-methyl-1H-pyrazole hydrochloride. LC-MS (ESI): m/z 506 [M+H]+; 2.90 min (ret time).

후처리

  1. custom2.90 min (ret time)

출처 및 근거

ORD 기록
ord-9a8f77a8f6ba43f98f91014ad59bd67e
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859573B2

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