2,4,5-Trichloropyrimidine → 3-(2,5-dichloropyrimidin-4-ylamino)pyridin-2(1H)-one

HRID 536331노트

반응식

HRID 536331 반응식
[NH2:1][C:2]1[C:3](=[O:8])[NH:4][CH:5]=[CH:6][CH:7]=1.[Cl:9][C:10]1[N:15]=[C:14](Cl)[C:13]([Cl:17])=[CH:12][N:11]=1.C([O-])(O)=O.[Na+]>CO.O>[Cl:9][C:10]1[N:15]=[C:14]([NH:1][C:2]2[C:3](=[O:8])[NH:4][CH:5]=[CH:6][CH:7]=2)[C:13]([Cl:17])=[CH:12][N:11]=1

참가 물질

6

반응물 3

HCID 2372592,4,5-TrichloropyrimidineHCID 3223533-Amino-2-pyridinolHCID 516892Sodium Bicarbonate

생성물 1

HCID 582551623-(2,5-dichloropyrimidin-4-ylamino)pyridin-2(1H)-one

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A mixture of 3-aminopyridin-2(1H)-one (99 mg, 0.90 mmol), 2,4,5-trichloropyrimidine (165 mg, 0.90 mmol, 1 equiv.) and NaHCO3 (76 mg, 0.90 mmol, 1 equiv.) in a mixture of MeOH (6 mL) and H2O (3 mL) was stirred at room temperature for 24 h. The resulting precipitate was collected by vacuum filtration and washed with small amounts of MeOH and water, providing the product 3-(2,5-dichloropyrimidin-4-ylamino)pyridin-2(1H)-one; ESMS m/z 257.0 (M+H+).

후처리

  1. filtrationThe resulting precipitate was collected by vacuum filtration
  2. washwashed with small amounts of MeOH and water

출처 및 근거

ORD 기록
ord-fa9713ee05d544e2a4f1809f20360022
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859574B2

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