Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2,5-Dichloro-N-(5-ethyl-1H-pyrazol-3-yl)pyrimidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| 반응물 | 3-ethyl-1H-pyrazol-5-amine | HCID 21991095 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2,5-Dichloro-N-(5-ethyl-1H-pyrazol-3-yl)pyrimidin-4-amine | HCID 58255148 | — |
반응 단계
A mixture of 5-ethyl-1H-pyrazol-3-amine (1.00 g, 6.77 mmol), 2,4,5-trichloropyrimidine (1.24 g, 6.77 mmol) and Na2CO3 (1.79 g, 16.9 mmol) in iso-propanol (15 mL) was stirred in a sealed vial at rt for two days. Water (10 mL) was added. The solid was collected by filtration, washed with water (10 mL) and dried to give 2,5-Dichloro-N-(5-ethyl-1H-pyrazol-3-yl)pyrimidin-4-amine as a light yellow solid; ESMS m/z 258.0 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08859574B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-5ebc5cc038894190ba0606688373b6e6 |
| 출처 메모 | uspto-grants-2014_10 |