Methanol → 4-amino-2,3-dihydro-1H-inden-2-ol

HRID 536446

반응식

HRID 536446 반응식
C([O:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:14])[CH2:6]1)(=O)C.CO.C(=O)([O-])[O-].[K+].[K+]>CC(O)C>[NH2:14][C:11]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:12]=1[CH2:13][CH:5]([OH:4])[CH2:6]2

참가 물질

5

반응물 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 132395844-amino-2,3-dihydro-1H-inden-2-yl acetate

생성물 1

HCID 545954264-amino-2,3-dihydro-1H-inden-2-ol수율 99%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A slurry of 4-amino-2,3-dihydro-1H-inden-2-yl acetate (12.6 g, 65.9 mmol; prepared according to US2003109700), MeOH (63 mL), and potassium carbonate (13.7 g, 99.0 mmol) was stirred at ambient temperature for 15 minutes. The reaction mixture was diluted with IPA (630 mL), passed through a plug of silica gel, washed with IPA (100 mL), and concentrated to give the title compound (9.70 g, 65.0 mmol, 99%). MS (DCI) m/z 267 (M+NH4)+.

후처리

  1. washwashed with IPA (100 mL)
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-228c365d383e4ceba0442cb320284762
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859584B2

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