Thionyl Chloride → 4-(Chloromethyl)-3-fluoropyridine hydrochloride

HRID 536485노트

반응식

HRID 536485 반응식
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8]O.S(Cl)([Cl:12])=O>C(#N)C>[ClH:12].[Cl:12][CH2:8][C:7]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[F:1]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 49760376(3-Fluoropyridin-4-yl)methanol

생성물 1

HCID 713062034-(Chloromethyl)-3-fluoropyridine hydrochloride

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

반응 조건

온도
50 °C

실험 절차

6.710 g (52.785 mmol) of (3-fluoropyridin-4-yl)methanol was put in 29 ml acetonitrile and heated to 50° C. Then a solution of 7.701 ml thionyl chloride in 14.5 ml acetonitrile was added dropwise and the reaction mixture was stirred for 4 h at 50° C. Then the reaction mixture was concentrated by evaporation and was co-distilled three times with dichloromethane. After drying under high vacuum, 10.27 g of the title compound was obtained, which was used in the next step without further purification.

후처리

  1. concentrationThen the reaction mixture was concentrated by evaporation
  2. customAfter drying under high vacuum

출처 및 근거

ORD 기록
ord-53cd80e5e96045c68d55a431d243c5a9
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859569B2

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