Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2-[4-(3-Oxo-1,2-benzothiazol-2-yl)phenyl]acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Aminophenylacetic acid | HCID 14533 | — |
| 반응물 | 2-(Chlorothio)-benzoyl chloride | HCID 10910715 | — |
| 용매 | Glycol monoethyl ether | HCID 8076 | — |
| 생성물 | 2-[4-(3-Oxo-1,2-benzothiazol-2-yl)phenyl]acetic acid | HCID 462937 | 69.4% |
반응 단계
To a mixture of 7.55 g (0.05 mol) of 4-aminophenylacetic acid and 15.15 g (0.15 mol) of triethylamine in 25 mL of ethyl cellosolve was added 10.3 g (0.05 mol) of 2-chlorosulfenylbenzoyl chloride (Arzneimittel Forsch., 1964;14:1301) . The mixture was stirred at room temperature for 3 hours, concentrated in vacuo, and water was added to the residue. The mixture was acidified with HCl and filtered to give 9.9 g of the title compound, mp 173°-175° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05620997 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-19bbb259259440cc8353ec428272db43 |
| 출처 메모 | uspto-grants-1997_04 |