Triethylamine → [4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	4-Amino-alpha-methylbenzenemethanol	HCID 85753	—
반응물	Triphosgene	HCID 94429	—
반응물	4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline	HCID 45379087	—
용매	Dichloromethane	HCID 6344	—
생성물	[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea	HCID 44515378	24%

반응 조건

온도	0 °C

반응 단계

To a stirred mixture of 4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline (0.140, 0.40 mmoles) in methylene chloride at 0° C. was added triphosgene (0.25, 0.84 mmoles) and Et3N (3 mL). The reaction mixture was stirred for 20 minutes at 0° C. Then 1-(4-aminophenyl)ethanol (0.10 g, 0.73 mmoles) was added to the mixture. The reaction mixture was stirred for about 16 hours at room temperature. The solvent was removed. The residue was dissolved in DMSO and place at HPLC using acetonitrile buffer TFA to give 48 mg (24%) of [4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea. M+H 506.4.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08859542B2
출처 데이터셋	uspto-grants-2014_10
ORD ID	ord-b1d7c0e41edf4ef88537f3d63acf6e49
출처 메모	uspto-grants-2014_10