Iodine → 2-(2-Morpholin-4-yl-ethyl)-6-phenyl-isothiazolo[5,4-d)pyrimidin-3-one

HRID 53686

반응식

HRID 53686 반응식
[N:1]1([CH2:7][CH2:8][NH:9][C:10]([C:12]2[C:13]([SH:24])=[N:14][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:16][CH:17]=2)=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.II>>[N:1]1([CH2:7][CH2:8][N:9]2[C:10](=[O:11])[C:12]3[C:13](=[N:14][C:15]([C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)=[N:16][CH:17]=3)[S:24]2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

참가 물질

3

반응물 2

HCID 807IodineHCID 1784182924-Mercapto-2-phenyl-pyrimidine-5-carboxylic acid (2-morpholin-4-yl-ethyl)-amide

생성물 1

HCID 232878822-(2-Morpholin-4-yl-ethyl)-6-phenyl-isothiazolo[5,4-d)pyrimidin-3-one수율 60.8%

실험 절차

Using the procedure of Example 20, 2.0 g (5.81 mmol) of 4-mercapto-2-phenyl-pyrimidine-5-carboxylic acid (2-morpholin-4-yl-ethyl)-amide were treated with 1.47 g (5.81 mmol) of iodine to give 1.21 g of the title compound after recrystallization from isopropanol, mp 163°-165° C.

출처 및 근거

ORD 기록
ord-936364b3dca5411eb29bb3f0e11f8fa7
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05620997

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