HCID 178418361, 화합물 → N-(4-amino-5-methylpyridin-2-yl)acetamide
반응식
[CH3:1][C:2]1[C:3]([N+:13]([O-])=O)=[CH:4][C:5]([NH:9][C:10](=[O:12])[CH3:11])=[N+:6]([O-])[CH:7]=1.[H][H]>CO.[OH-].[OH-].[Pd+2]>[NH2:13][C:3]1[C:2]([CH3:1])=[CH:7][N:6]=[C:5]([NH:9][C:10](=[O:12])[CH3:11])[CH:4]=1참가 물질
5
실험 절차
A mixture of N-(5-methyl-4-nitro-1-oxidopyridin-2-yl)acetamide (3.1 g, 14.7 mmol) and Pd(OH)2 (20% on carbon, 1.6 g) in MeOH (80 mL) was allowed to stir under 40 psi of hydrogen at rt for 6 days. The reaction mixture was then filtered over celite and the filter cake was washed with DCM. The filtrate was concentrated to give N-(4-amino-5-methylpyridin-2-yl)acetamide (2.1 g, 86%) which was used without further purification.
후처리
- filtrationThe reaction mixture was then filtered over celite
- washthe filter cake was washed with DCM
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-bc8f879f10754d499ec1db3f0fcd5976
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08859768B2
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