2,4-Dimethoxybenzylamine → N-(2,4-dimethoxybenzyl)-4-iodo-5-methylpyridin-2-amine

HRID 537027

반응식

HRID 537027 반응식
F[C:2]1[CH:7]=[C:6]([I:8])[C:5]([CH3:9])=[CH:4][N:3]=1.[CH3:10][O:11][C:12]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=1[CH2:20][NH2:21]>CCOC(C)=O>[CH3:10][O:11][C:12]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=1[CH2:20][NH:21][C:2]1[CH:7]=[C:6]([I:8])[C:5]([CH3:9])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 5972502,4-DimethoxybenzylamineHCID 100600522-Fluoro-4-iodo-5-methylpyridine

생성물 1

HCID 66747638N-(2,4-dimethoxybenzyl)-4-iodo-5-methylpyridin-2-amine수율 57%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
110 °C

실험 절차

A mixture of 2-fluoro-4-iodo-5-methylpyridine (60 g, 253 mmol) and 1-(2,4-dimethoxyphenyl)methanamine (190.6 mL, 1270 mmol) was allowed to stir at 110° C. overnight. The mixture was allowed to cool to rt and was then diluted with EtOAc (190 mL). The resulting solid was filtered and washed with EtOAc and then purified by column chromatography to give N-(2,4-dimethoxybenzyl)-4-iodo-5-methylpyridin-2-amine (55.0 g, 57%).

후처리

  1. temperatureto cool to rt
  2. filtrationThe resulting solid was filtered
  3. washwashed with EtOAc
  4. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-325d4bda78d84a6fa902d9be0996752d
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859768B2

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