Trifluoroacetic acid → HCID 178474095, 화합물

HRID 537049노트

반응식

HRID 537049 반응식
C(O)(C(F)(F)F)=O.[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[O:19][C:18]([C:20]2[CH:25]=[CH:24][C:23]([NH:26][C:27](=[O:29])[CH3:28])=[CH:22][CH:21]=2)=[N:17][C:16]=1[C:30]1[N:34](COCC[Si](C)(C)C)[CH:33]=[N:32][N:31]=1>C(Cl)Cl>[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[O:19][C:18]([C:20]2[CH:21]=[CH:22][C:23]([NH:26][C:27](=[O:29])[CH3:28])=[CH:24][CH:25]=2)=[N:17][C:16]=1[C:30]1[N:34]=[CH:33][NH:32][N:31]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 66749648N-{4-[5-(2-chlorophenyl)-4-(4-{[2-(trimethylsilyl)ethoxy]methyl}-4H-1,2,4-triazol-3-yl)-1,3-oxazol-2-yl]phenyl}acetamide

생성물 1

HCID 178474095HCID 178474095, 화합물수율 34.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

TFA (0.6 mL) was added to a solution of N-{4-[5-(2-chlorophenyl)-4-(4-{[2-(trimethylsilyl)ethoxy]methyl}-4H-1,2,4-triazol-3-yl)-1,3-oxazol-2-yl]phenyl}acetamide (0.10 g, 0.20 mmol) in DCM (3 mL). The reaction mixture was allowed to stir at rt overnight and then concentrated. The residue was purified by column chromatography to give N-{4-[5-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1,3-oxazol-2-yl]phenyl}acetamide (Compound I-8) (0.026 g, 32%). LCMS (FA): m/z=380 (M+H).

후처리

  1. concentrationconcentrated
  2. customThe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-fa0f5e72f67a4481a9c2259290808180
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859768B2

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