Trifluoroacetic acid → HCID 178474033, 화합물

HRID 537070노트

반응식

HRID 537070 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:4][C:3]=1[C:14]1[O:18][C:17]([C:19]2[C:24]([CH3:25])=[CH:23][N:22]=[C:21]([NH:26][C:27](=[O:29])[CH3:28])[CH:20]=2)=[CH:16][C:15]=1[C:30]1[N:34]=[CH:33][N:32](COCC[Si](C)(C)C)[N:31]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:10][CH2:11][CH2:12][CH2:13]2)=[CH:4][C:3]=1[C:14]1[O:18][C:17]([C:19]2[C:24]([CH3:25])=[CH:23][N:22]=[C:21]([NH:26][C:27](=[O:29])[CH3:28])[CH:20]=2)=[CH:16][C:15]=1[C:30]1[NH:34][CH:33]=[N:32][N:31]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 66749388N-(4-{5-[2-chloro-5-(pyrrolidin-1-ylmethyl)phenyl]-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-2-furyl}-5-methylpyridin-2-yl)acetamide

생성물 1

HCID 178474033HCID 178474033, 화합물수율 86.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of N-(4-{5-[2-chloro-5-(pyrrolidin-1-ylmethyl)phenyl]-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-2-furyl}-5-methylpyridin-2-yl)acetamide (0.20 g, 0.34 mmol) in DCM (5 mL) was added TFA (2 mL). The mixture was allowed to stir at rt overnight. The mixture was concentrated and the residue was purified by column chromatography to give N-(4-{5-[2-chloro-5-(pyrrolidin-1-ylmethyl)phenyl]-4-(4H-1,2,4-triazol-3-yl)-2-furyl}-5-methylpyridin-2-yl)acetamide (0.14 g, 81%). LCMS (FA): m/z=477.6 (M+H).

후처리

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-4fd36a0f84424a78a9c6a8e6425807b2
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859768B2

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