Methanesulfonyl chloride → Methyl 3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoate

HRID 537235노트

반응식

HRID 537235 반응식
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:13]=[CH:14][C:15]=2[NH2:16])[C:9]([O:11][CH3:12])=[O:10])[CH2:3][CH2:2]1.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>N1C=CC=CC=1>[CH3:12][O:11][C:9](=[O:10])[C:8]1[CH:13]=[CH:14][C:15]([NH:16][S:18]([CH3:17])(=[O:20])=[O:19])=[C:6]([O:5][CH2:4][CH:1]2[CH2:3][CH2:2]2)[CH:7]=1

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 43560608HCID 43560608, 화합물

생성물 1

HCID 59443764Methyl 3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoate

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Methyl 3-(cyclopropylmethoxy)-4-aminobenzoate (8.86 g) was dissolved in pyridine (80 mL) at room temperature under N2 atmosphere. Methanesulfonyl chloride (4.04 mL) was added and the mixture was stirred at r.t. for 18 hours. The reaction mixture was evaporated to dryness, the crude was treated with 1N HCl (500 mL) and extracted with CH2Cl2 (3×200 mL). The organic layer was dried over Na2SO4 and the solvent was evaporated off to yield 11.7 g of the desired intermediate.

후처리

  1. customThe reaction mixture was evaporated to dryness
  2. additionthe crude was treated with 1N HCl (500 mL)
  3. extractionextracted with CH2Cl2 (3×200 mL)
  4. dry with materialThe organic layer was dried over Na2SO4
  5. customthe solvent was evaporated off

출처 및 근거

ORD 기록
ord-fb1ddea00f7b41f187b7f5b6f5e94960
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859778B2

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