1,4-Dioxane hydrochloride → HCID 67110944, 화합물

HRID 537352노트

반응식

HRID 537352 반응식
[ClH:1].O1CCOCC1.[C:8]([C:10]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[CH2:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]1)#[N:9]>>[ClH:1].[C:8]([C:10]1([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[CH2:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)#[N:9]

참가 물질

3

반응물 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68160870HCID 68160870, 화합물

생성물 1

HCID 67110944HCID 67110944, 화합물수율 99%

실험 절차

4 M HCl/dioxane (905 μL, 3.62 mmol) was added to neat tert-butyl 4-cyano-4-(2-(3-ethoxy-3-oxopropyl)phenyl)piperidine-1-carboxylate at 23° C. and was stirred for 2 h. The solution was concentrated to yield ethyl 3-(2-(4-cyanopiperidin-4-yl)phenyl)propanoate hydrochloride (22, 230 mg, 99% yield over 2 steps).

후처리

  1. concentrationThe solution was concentrated

출처 및 근거

ORD 기록
ord-c3cfbb1a38134c4bac2016a9bc1a304f
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859776B2

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