2-Chlorocinnamaldehyde → HCID 91338103, 화합물

HRID 537398노트

반응식

HRID 537398 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([CH3:10])C=O)[CH:2]=1.[C:11]([O:15][C:16](=[O:37])[NH:17][CH:18]([C:28]([N:30]1[CH2:35][CH2:34][CH:33]([CH3:36])[CH2:32][CH2:31]1)=[O:29])CCC1C=CC=CC=1Cl)([CH3:14])([CH3:13])[CH3:12].ClC1C=CC=CC=1C=CC=O>>[C:11]([O:15][C:16](=[O:37])[NH:17][CH:18]([C:28]([N:30]1[CH2:35][CH2:34][CH:33]([CH3:36])[CH2:32][CH2:31]1)=[O:29])[CH2:10][CH2:7][C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)([CH3:14])([CH3:12])[CH3:13]

참가 물질

4

반응물 3

HCID 30140422-ChlorocinnamaldehydeHCID 18461044HCID 18461044, 화합물HCID 131731949Tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate

생성물 1

HCID 91338103HCID 91338103, 화합물

실험 절차

tert-Butyl{1-[(4-methylpiperidin-1-yl)carbonyl]-3-pyridin-3-ylpropyl}carbamate is prepared from pyridin-3-yl propionaldehyde (Kitbunnadaj, R. et al. J. Med. Chem, 2004, 47, 2414-2417) in the same manner that tert-butyl{3-(2-chlorophenyl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}carbamate is prepared from 3-(2-chlorophenyl)propenal in Example 5.

출처 및 근거

ORD 기록
ord-aa73e8077ebb4b569bf242e162c30191
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859814B2

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