Oxalyl chloride → 3,3-Dimethylcyclobutane-1-carbonyl chloride

HRID 537460

반응식

HRID 537460 반응식
[CH3:1][C:2]1([CH3:9])[CH2:5][CH:4]([C:6](O)=[O:7])[CH2:3]1.C(Cl)(=O)C([Cl:13])=O>ClCCl.CN(C)C=O>[CH3:1][C:2]1([CH3:9])[CH2:5][CH:4]([C:6]([Cl:13])=[O:7])[CH2:3]1

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 2151063,3-Dimethylcyclobutanecarboxylic acid

생성물 1

HCID 205352373,3-Dimethylcyclobutane-1-carbonyl chloride수율 100%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

To a 0° C. solution of 3,3-dimethylcyclobutanecarboxylic acid (1.35 g, 10.5 mmol) in dichloromethane (10 mL) was slowly added oxalyl chloride (4.01 g, 31.6 mmol) and 1 drop of N,N-dimethylformamide. The reaction was warmed to room temperature and stirred for 2 hours. The reaction was concentrated in vacuo to give crude 3,3-dimethylcyclobutanecarbonylchloride (1.54 g) as a yellow oil.

후처리

  1. customTo a 0° C.
  2. concentrationThe reaction was concentrated in vacuo

출처 및 근거

ORD 기록
ord-f6fe8d442e40482e9aa1047922ee3ebe
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859591B2

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