Oxalyl chloride → 3,3-Dimethylcyclobutane-1-carbonyl chloride

HRID 537483

반응식

HRID 537483 반응식
[CH3:1][C:2]1([CH3:9])[CH2:5][CH:4]([C:6](O)=[O:7])[CH2:3]1.C(Cl)(=O)C([Cl:13])=O>ClCCl>[CH3:1][C:2]1([CH3:9])[CH2:5][CH:4]([C:6]([Cl:13])=[O:7])[CH2:3]1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 2151063,3-Dimethylcyclobutanecarboxylic acid

생성물 1

HCID 205352373,3-Dimethylcyclobutane-1-carbonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3,3-Dimethyl-cyclobutanecarboxylic acid (Parkway Scientific, New York, N.Y., USA) (500 mg, 3.90 mmol) was dissolved in dichloromethane (3 mL) and oxalyl chloride (1.02 mL, 11.7 mmol) was added. The solution was stirred at room temperature for 4 h before concentrating in vacuo to provide 3,3-dimethylcyclobutanecarbonyl chloride which was carried on without purification. 1H NMR (400 MHz, CDCl3) δ 3.49 (quin, J=8.9 Hz, 1H) 2.27-2.15 (m, 2H) 2.14-2.06 (m, 2H) 1.18 (s, 3H) 1.12 (s, 3H).

후처리

  1. concentrationbefore concentrating in vacuo

출처 및 근거

ORD 기록
ord-eb17c0b1590747acbce828d1da2415cf
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859591B2

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