Oxalyl chloride → 3,3-Difluorocyclobutanecarbonyl chloride

HRID 537487노트

반응식

HRID 537487 반응식
[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6](O)=[O:7])[CH2:3]1.C(Cl)(=O)C([Cl:13])=O>ClCCl>[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6]([Cl:13])=[O:7])[CH2:3]1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 137777893,3-Difluorocyclobutane-1-carboxylic acid

생성물 1

HCID 838550033,3-Difluorocyclobutanecarbonyl chloride수율 50%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3,3-Difluorocyclobutanecarboxylic acid (Parkway Scientific, New York, N.Y., USA) (531 mg, 3.90 mmol) was dissolved in dichloromethane (3.00 mL) and oxalyl chloride (1.02 mL, 11.7 mmol) was added. The solution was stirred at room temperature for 4 h before concentrating in vacuo to provide 3,3-difluorocyclobutanecarbonyl chloride (ca. 50% pure), which was carried on without purification.

후처리

  1. concentrationbefore concentrating in vacuo

출처 및 근거

ORD 기록
ord-8f0abb41d77c4158a9788c9c01380702
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859591B2

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