Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 537865생성일: 2026년 10월 24일
N-(3-Aminophenyl)-1-phenylmethanesulfonamide → 1-phenyl-N-(3-((5-(4-(trifluoromethyl)phenyl)oxazol-2-yl)amino)phenyl)methane sulfonamide
https://huagongshe.com/ko/reaction/537865
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N-(3-Aminophenyl)-1-phenylmethanesulfonamide | HCID 16772451 | — |
| 반응물 | 2-Chloro-5-(4-(trifluoromethyl)phenyl)oxazole | HCID 71060395 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 1-phenyl-N-(3-((5-(4-(trifluoromethyl)phenyl)oxazol-2-yl)amino)phenyl)methane sulfonamide | HCID 71060466 | — |
반응 단계
A mixture of 2-chloro-5-(4-(trifluoromethyl)phenyl)oxazole 31 (0.651 g, 2.63 mmol) and N-(3-aminophenyl)-1-phenylmethanesulfonamide 26 (0.69 g, 2.63 mmol) in 2-propanol (50 mL) was heated to 80° C. for 18 h with stirring. Upon cooling, solvent was evaporated and silica column purified (Biotage) (Acetone/hexane as an eluent) to provide 1-phenyl-N-(3-((5-(4-(trifluoromethyl)phenyl)oxazol-2-yl)amino) phenyl) methane sulfonamide. 34 (0.407 g, 33% yield) as a solid. MS (ES) m/z 474 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08865709B2 |
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| 출처 데이터셋 | uspto-grants-2014_10 |
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| ORD ID | ord-f52227b5f0b2481287114cf7e02f9353 |
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| 출처 메모 | uspto-grants-2014_10 |
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