Thionyl Chloride → 2-Chloromethyl-1-methyl-4-phenyl-1H-imidazole

반응식

[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:4]=[C:3]1[CH2:13]O.O=S(Cl)[Cl:17]>>[Cl:17][CH2:13][C:3]1[N:2]([CH3:1])[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:4]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 23076602(1-Methyl-4-phenyl-1H-imidazol-2-yl)-methanol

생성물 1

HCID 591512282-Chloromethyl-1-methyl-4-phenyl-1H-imidazole

실험 절차

To a solution of (1-Methyl-4-phenyl-1H-imidazol-2-yl)-methanol 5 (0.2 g, 0.097 mmol) was added SOCl2 (0.14 g, 0.121 mmol), and the mixture was stirred at room temperature overnight. The mixture was evaporated to afford 2-Chloromethyl-1-methyl-4-phenyl-1H-imidazole 6, which was used without purification. 1H NMR (400 MHz, DMSO-d6): δ8.24 (s, 1H), 7.87 (d, J=6.8 Hz, 2H), 7.54-7.49 (m, 2H), 7.43-7.41 (m, 1H), 5.24 (s, 2H), 3.89 (s, 3H).

후처리

customThe mixture was evaporated

출처 및 근거

ORD 기록: ord-ccace1d1a25e46c388f02e1afcf1c5ca
출처 데이터셋: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08865711B2

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