Water → HCID 178487289, 화합물

HRID 538080노트

반응식

HRID 538080 반응식
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C@H:23]2[CH2:28][CH2:27][C@H:26]([CH2:29][N:30]3[C:34]4[CH:35]=[C:36]([O:39][CH3:40])[CH:37]=[CH:38][C:33]=4[N:32]([CH3:41])[C:31]3=[O:42])[CH2:25][CH2:24]2)=[O:22])[CH2:17][CH2:16]1)=O)(C)(C)C.O>C(Cl)Cl>[CH3:40][O:39][C:36]1[CH:37]=[CH:38][C:33]2[N:32]([CH3:41])[C:31](=[O:42])[N:30]([CH2:29][C@H:26]3[CH2:27][CH2:28][C@H:23]([C:21]([N:18]4[CH2:17][CH2:16][NH:15][CH2:20][CH2:19]4)=[O:22])[CH2:24][CH2:25]3)[C:34]=2[CH:35]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 178487291HCID 178487291, 화합물

생성물 1

HCID 178487289HCID 178487289, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoro acetic acid (8 ml) was added to a solution of trans-4-[4-(6-Methoxy-3-methyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexanecarbonyl]-piperazine-1-carboxylic acid tert-butyl ester in DCM (19 ml). The solution was stirred at room temperature overnight and then 10 ml of water were added. The mixture was concentrated under reduced pressure and DCM (20 ml) were added. The organic solution was washed with a saturated solution of NaHCO3 (2×20 ml), dried over Na2SO4, filtered and the solvent evaporated to give the titled compound

후처리

  1. concentrationThe mixture was concentrated under reduced pressure and DCM (20 ml)
  2. additionwere added
  3. washThe organic solution was washed with a saturated solution of NaHCO3 (2×20 ml)
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-cad873a1b0604ff5bec90fe1d7ef3a79
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08865704B2

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