참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 4-Fluorobenzamide | HCID 71572 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Fluorobenzoyl isocyanate | HCID 2733375 | 100.9% |
반응 단계
To a solution of 4-fluorobenzamide (1 g, 7.2 mmol) in DCM (25 mL) was added slowly oxalylchloride (0.76 mL, 8.62 mmol). The mixture was heated to 50° C. for ˜18 hr. The mixture was allowed to cool to room temperature and concentrated in vacuo to afford crude 4-fluorobenzoyl isocyanate (1.2 g). The crude material was used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08865732B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_10 |
|---|
| ORD ID | ord-2036fb3f31d74ad28e98521a32791a68 |
|---|
| 출처 메모 | uspto-grants-2014_10 |
|---|
