Hexane → 2,6-Di-tert-butyl-4-(2-nitrostyryl)phenol

HRID 53852

반응식

HRID 53852 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH:10]=[C:11]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:12]=1[OH:13])[CH:8]=O)([CH3:4])([CH3:3])[CH3:2].[N+:18]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27]C(O)=O)([O-:20])=[O:19].N1CCCCC1.CCCCCC>C1(C)C(C)=CC=CC=1>[C:1]([C:5]1[CH:6]=[C:7]([CH:8]=[CH:27][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N+:18]([O-:20])=[O:19])[CH:10]=[C:11]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:12]=1[OH:13])([CH3:4])([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 8058HexaneHCID 8082PiperidineHCID 732193,5-Di-tert-butyl-4-hydroxybenzaldehydeHCID 77337(2-Nitrophenyl)acetic acid

생성물 1

HCID 541417492,6-Di-tert-butyl-4-(2-nitrostyryl)phenol수율 62.9%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

To a solution of 3,5-di-tert-butyl-4-hydroxybenzaldehyde (8.09 g, 34.5 mmol) and 2-nitrophenylacetic acid (9.40 g, 51.9 mmol) in xylene (60 ml) was added piperidine (0.3 ml) and the mixture was heated under reflux for 26 hrs while removing water producing with the progress of reaction. After allowing to stand overnight, hexane was added to afford as crystals 2,6-di-tert-butyl-4-(2-nitrostyryl)phenol (7.67 g, 62.9%).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 26 hrs
  3. customwhile removing water producing
  4. customwith the progress of reaction

출처 및 근거

ORD 기록
ord-3925ace3a9be4734b0ae067507043c4f
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05621010

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