2-Amino-4-methylbenzothiazole → 2,6-Difluoro-3-[(4-methyl-1,3-benzothiazol-2-yl)methoxy]benzenecarboxamide

HRID 538544

반응식

HRID 538544 반응식
[CH3:1][C:2]1[C:7]2[N:8]=[C:9](N)[S:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.C([CH2:14][O:15][C:16]1[C:17]([F:26])=[C:18]([C:23]([NH2:25])=[O:24])[C:19]([F:22])=[CH:20][CH:21]=1)#N>>[F:26][C:17]1[C:16]([O:15][CH2:14][C:9]2[S:10][C:6]3[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[C:7]=3[N:8]=2)=[CH:21][CH:20]=[C:19]([F:22])[C:18]=1[C:23]([NH2:25])=[O:24]

참가 물질

3

반응물 2

HCID 151322-Amino-4-methylbenzothiazoleHCID 594028043-(Cyanomethoxy)-2,6-difluorobenzenecarboxamide

생성물 1

HCID 462372672,6-Difluoro-3-[(4-methyl-1,3-benzothiazol-2-yl)methoxy]benzenecarboxamide수율 36%

실험 절차

Synthesised from 4-methyl-1,3-benzothiazol-2-amine and 3-(cyanomethoxy)-2,6-difluorobenzene carboxamide, according to Method K, scheme 26. Yield 36% (second step), mp 201-202° C., HPLC-MS (method 1): m/z 335 [M+H]+, Rt=3.79 min.

출처 및 근거

ORD 기록
ord-08c46133eca9495bb784814ae5fd452f
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08865736B2

연결된 노트

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