Thiophene, 2,3,5-tribromo- → HCID 68294091, 화합물

HRID 538730

반응식

HRID 538730 반응식
[Br:1]C1SC(Br)=CC=1Br.COC1C=C(B(O)O)C=CC=1OC.[CH3:22][O:23][C:24]1[CH:25]=[C:26]([C:32]2[S:33][C:34]([C:37]3[CH:42]=[CH:41][C:40]([O:43][CH3:44])=[C:39]([O:45][CH3:46])[CH:38]=3)=[CH:35][CH:36]=2)[CH:27]=[CH:28][C:29]=1[O:30][CH3:31]>>[Br:1][C:36]1[CH:35]=[C:34]([C:37]2[CH:42]=[CH:41][C:40]([O:43][CH3:44])=[C:39]([O:45][CH3:46])[CH:38]=2)[S:33][C:32]=1[C:26]1[CH:27]=[CH:28][C:29]([O:30][CH3:31])=[C:24]([O:23][CH3:22])[CH:25]=1

참가 물질

4

반응물 3

HCID 76592Thiophene, 2,3,5-tribromo-HCID 27347023,4-Dimethoxyphenylboronic acidHCID 68293971HCID 68293971, 화합물

생성물 1

HCID 68294091HCID 68294091, 화합물수율 77%

실험 절차

3-bromo-2,5-bis(3′,4′-dimethoxyphenyl)thiophene (18) was prepared by the reaction of 2,3,5-tribromothiophene (17) (321 mg, 1 mmol) and (3,4-dimethoxyphenyl)boronic acid (15) (419 mg, 2.3 mmol) according to the similar procedure for compound 16. The reaction mixture was purified by column chromatography (10%-30% EtOAc in hexanes) and afforded 18 (337 mg, 77% yield) as a yellow solid. SA-60 was also isolated (97 mg, 20% yield) from the reaction above as a dark yellow solid.

후처리

  1. customThe reaction mixture was purified by column chromatography (10%-30% EtOAc in hexanes)

출처 및 근거

ORD 기록
ord-c9424669ef044bb084bf5f0461862c97
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08865754B2

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