4-(Bromomethyl)thiazole → HCID 178490656, 화합물

HRID 538805노트

반응식

HRID 538805 반응식
[Br:1][C:2]1[S:6][C:5]([NH:7][C:8](=[O:18])[C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[O:16][CH3:17])=[N:4][CH:3]=1.Br[CH2:20][C:21]1[N:22]=[CH:23][S:24][CH:25]=1>>[Br:1][C:2]1[S:6]/[C:5](=[N:7]\[C:8](=[O:18])[C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[O:16][CH3:17])/[N:4]([CH2:20][C:21]2[N:22]=[CH:23][S:24][CH:25]=2)[CH:3]=1

참가 물질

3

반응물 2

HCID 98989844-(Bromomethyl)thiazoleHCID 60654877N-(5-bromothiazol-2-yl)-5-chloro-2-methoxybenzamide

생성물 1

HCID 178490656HCID 178490656, 화합물수율 52%

실험 절차

A mixture of Example 84A (1001 mg, 3.33 mmol) and commercially available 4-(bromomethyl)thiazole were processed using the method described for Example 83B to afford the title compound (660 mg, 52% yield). 1H NMR (300 MHz, DMSO-d6) δ ppm 3.78 (s, 3H), 5.54 (s, 2H), 7.12 (d, J=9.2 Hz, 1H), 7.49 (dd, J=8.8, 2.7 Hz, 1H), 7.69 (dd, J=15.9, 2.4 Hz, 2H), 7.93 (s, 1H), 9.10 (d, J=2.0 Hz, 1H) MS (DCI) m/z 445 (M+H)+; Anal. Calculated for C15H11BrClN3O2S2: C, 40.51; H, 2.49; N, 9.45. Found: C, 40.85; H, 2.90; N, 9.62.

출처 및 근거

ORD 기록
ord-5edd82e1a923424fa65cd833e0997f28
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08865753B2

반응 노트

불러오는 중…