참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Iodoethane | HCID 6340 | — |
| 반응물 | N-(4-Butyrylphenyl)acetamide | HCID 4304236 | — |
| 반응물 | Lithium diisopropylamide mono(tetrahydrofuran) | HCID 10997623 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(4-(2-ethylbutanoyl)phenyl)acetamide | HCID 43160160 | — |
반응 단계
To a solution of N-(4-butyrylphenyl)acetamide (3 g, 14.6 mmol) in THF (300 mL) was added 2.0 M LDA THF (18.3 mL) at −78° C. and then the reaction mixture was stirred for 1 h at −78° C. Iodoethane was added and stirred overnight at RT. The reaction mixture was quenched with sat. aq. NH4Cl and then extracted with ethyl acetate. The combined organic layers were dried over MgSO4, filtered and then concentrated. The crude product was purified by preparative TLC using 50% ethyl acetate in hexane as eluent to afford N-(4-(2-ethylbutanoyl)phenyl)acetamide as white solid. MS (ES+): m/z 234.28 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08865752B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_10 |
|---|
| ORD ID | ord-fecdf382f0564c6ebddbfea5285b64fe |
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| 출처 메모 | uspto-grants-2014_10 |
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