Sodium Bicarbonate → HCID 86681898, 화합물
반응식
[Br:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH2:11][CH2:12][CH2:13][CH3:14])[CH:8]=[CH:7][C:5]=2[N:6]=1.C(=O)(O)[O-:16].[Na+]>C(O)(=O)C>[Br:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([C:11](=[O:16])[CH2:12][CH2:13][CH3:14])[CH:8]=[CH:7][C:5]=2[N:6]=1참가 물질
4
실험 절차
Step-3: To a solution of 2-bromo-6-butylbenzo[d]thiazole in acetic acid at 0° C. was added CrO3 in acetic acid. The reaction mixture was allowed to warm to RT and stirred over 2 days. The reaction was neutralized by aq. sodium bicarbonate and extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate and concentrated, The crude product was purified by preparative TLC to afford 1-(2-bromobenzo[d]thiazol-6-yl)butan-1-one. MS (ESI+) m/z 286.2 [M+2]+
후처리
- extractionextracted with ethyl acetate
- washwashed with brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated
- customThe crude product was purified by preparative TLC
출처 및 근거
- ORD 기록
- ord-f87d2f5edd00415c8c6e0e359942bca9
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08865752B2
반응 노트
불러오는 중…