Sodium Methoxide → 4-(Methoxymethyl)-4-methyloxazolidin-2-one

HRID 539109노트

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HRID 539109 반응식
CC1C=CC(S([O:11][CH2:12][C:13]2([CH3:19])[CH2:17][O:16][C:15](=[O:18])[NH:14]2)(=O)=O)=CC=1.[CH3:20][O-].[Na+]>CO.O>[CH3:20][O:11][CH2:12][C:13]1([CH3:19])[CH2:17][O:16][C:15](=[O:18])[NH:14]1

참가 물질

5

반응물 2

HCID 10942334Sodium MethoxideHCID 57461222(4-Methyl-2-oxooxazolidin-4-yl)methyl 4-methylbenzenesulfonate

생성물 1

HCID 655855284-(Methoxymethyl)-4-methyloxazolidin-2-one수율 85%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a round bottom flask containing (4-methyl-2-oxooxazolidin-4-yl)methyl 4-methylbenzenesulfonate (300 mg, 1.05 mmol) was added under a nitrogen atmosphere 3 ml of sodium methoxide in methanol solution (25% wt). The resulting thick suspension was stirred at ambient temperature for 24 hours, and then heated at 80° C. for 18 hours. The reaction was cooled to ambient temperature, diluted with water, and the pH was adjusted to neutral. The mixture was concentrated, and the resulting solids were extracted with DCM and EtOAc. The combined organic layer was concentrated to afford 4-(methoxymethyl)-4-methyloxazolidin-2-one (129 mg, 85%) as an oil.

후처리

  1. temperatureheated at 80° C. for 18 hours
  2. temperatureThe reaction was cooled to ambient temperature
  3. concentrationThe mixture was concentrated
  4. extractionthe resulting solids were extracted with DCM and EtOAc
  5. concentrationThe combined organic layer was concentrated

출처 및 근거

ORD 기록
ord-9cfd8d0d48544e7cb0673e2f782cb389
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08865726B2

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