돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 539388생성일: 2026년 10월 26일

Chloride → 5-Norbornene 2-methylcinnamate

https://huagongshe.com/reaction/539388

반응식

참여 물질

역할이름HCID투입량
반응물ChlorideHCID 312—
반응물TriethylamineHCID 8471—
반응물Ethyl AcetateHCID 8857—
반응물Bicyclo(2.2.1)hept-5-ene-2-methanolHCID 78946—
용매TetrahydrofuranHCID 8028—
생성물5-Norbornene 2-methylcinnamateHCID 8660645788%

반응 조건

온도0 °C

반응 단계

15 g (0.121 mol) of the 5-norbornene-2-methanol prepared in Example 1, 61.2 g (0.605 mol) of triethylamine (produced from Aldrich Inc.), and 20 ml of THF were loaded into a 250 ml 2-neck flask and then stirred at 0° C. in an ice-water bath. 22.1 g (0.133 mol) of cinamoil chloride dissolved in 60 ml of THF was slowly added to the prepared mixture using an additional flask for 10 minutes. Then, the temperature of the reactant was increased to room temperature and then stirred for one hour. The resulting solution was diluted using an ethyl acetate. The diluted solution was loaded into a separatory funnel, washed using water and NaHCO3 several times, and then distilled in at a reduced pressure to remove a solvent. The result was refined using a column chromatography (Hexane: Ethyl acetate=20:1) to attain a product. (Yield: 88%)

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호USRE045219E1
출처 데이터셋uspto-grants-2014_10
ORD IDord-b12ebf1f8c3b405fb78ffbe9a5a21978
출처 메모uspto-grants-2014_10