1-Phenylaziridine → N-(2-cyclopentadienylethyl)aniline
반응식
[CH:1]1([Li:6])[CH:5]=[CH:4][CH:3]=[CH:2]1.[C:7]1([N:13]2[CH2:15][CH2:14]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[CH:1]1([CH2:15][CH2:14][NH:13][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH:5]=[CH:4][CH:3]=[CH:2]1.[CH:1]1([Li:6])[CH:5]=[CH:4][CH:3]=[CH:2]1참가 물질
실험 절차
Reaction of cyclopentadienyllithium II1 with N-phenylaziridine III1 to give N-(2-cyclopentadienylethyl)aniline IV1 ##STR8## 0.36 g (5 mmol) of cyclopentadienyllithium was added in several portions to a solution of 0.6 g (=5 mmol) of N-phenylaziridine in 50 ml of tetrahydrofuran (THF) under an argon atmosphere at -30° C. After the addition was complete, the mixture was stirred at -30° C. for 1 hour and then warmed to room temperature over the course of 12 hours. Then 50 ml of a saturated aqueous NH4Cl solution were added, the mixture was stirred for 1 hour and the organic phase was separated off. The latter was dried over anhydrous Na2SO4 and filtered, and the solvent was removed under oil pump vacuum. 0.83 g (4.5 mmol, 90% of theory) of IV1 was obtained as a yellow oil.
출처 및 근거
- ORD 기록
- ord-1fa31f14c32a425baf54c92e92cb7a97
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05621127
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