Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 1-Phenyltriazolylmethyl-3-hydroxypyridine-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Boron tribromide | HCID 25134 | — |
| 반응물 | 1-Phenyltriazolylmethyl-3-methoxypyridine-2-one | HCID 178487642 | — |
| 생성물 | 1-Phenyltriazolylmethyl-3-hydroxypyridine-2-one | HCID 178516886 | 61.1% |
반응 단계
Reaction of 151a (0.212 g, 0.75 mmol) and 1M BBr3 in CH2Cl2 (1.5 equiv) within 48 h as described for the synthesis of 148a gave compound 152a (0.123 g, 61%) as light brown solid. 1H NMR (DMSO-d6, 400 MHz) δ 5.27 (2H, s), 6.13 (1H, t, J=6.4), 6.67 (1H, d, J=7.2), 7.30 (1H, d, J=5.6), 7.45-7.49 (1H, m), 7.57 (2H, t, J=7.6), 7.87 (2H, d, J=8.0), 8.73 (1H, s), 9.08 (1H, s); 13C NMR (101 MHz, CDCl3) δ 136.59, 129.60, 128.94, 122.29, 120.62, 107.99, 29.29. (quaternary carbons were not seen). HRMS (EI) calcd for C14H12N4O2 [M]+ 268.0960. found 268.0967.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08871728B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-5330f9f182aa4b03843cfa55a6973f0d |
| 출처 메모 | uspto-grants-2014_10 |