Semicarbazide → 5-{1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-1H-pyrazol-3-yl}-2-methyl-phenylamine Semicarbazide

HRID 539642노트

반응식

[C:1]([Si:5]([CH3:24])([CH3:23])[O:6][CH2:7][CH2:8][N:9]1[C:13]([CH3:14])=[CH:12][C:11]([C:15]2[CH:16]=[CH:17][C:18]([CH3:22])=[C:19]([NH2:21])[CH:20]=2)=[N:10]1)([CH3:4])([CH3:3])[CH3:2].[NH2:25][NH:26][C:27]([NH2:29])=[O:28].C(Cl)(Cl)=O.NN>>[NH2:25][NH:26][C:27]([NH2:29])=[O:28].[C:1]([Si:5]([CH3:24])([CH3:23])[O:6][CH2:7][CH2:8][N:9]1[C:13]([CH3:14])=[CH:12][C:11]([C:15]2[CH:16]=[CH:17][C:18]([CH3:22])=[C:19]([NH2:21])[CH:20]=2)=[N:10]1)([CH3:3])([CH3:2])[CH3:4]

참가 물질

반응물 4

HCID 5196Semicarbazide

HCID 6371Phosgene

HCID 9321Hydrazine

HCID 66955104HCID 66955104, 화합물

생성물 1

HCID 670436225-{1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-1H-pyrazol-3-yl}-2-methyl-phenylamine Semicarbazide

실험 절차

5-{1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-1H-pyrazol-3-yl}-2-methyl-phenylamine was converted to the corresponding semicarbazide by treatment with phosgene followed by hydrazine, as described above in step 4 of preparation 7.

후처리

customas described above in step 4 of preparation 7

출처 및 근거

ORD 기록: ord-a0eef354119748a3b4927fe6397d47c3
출처 데이터셋: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08871760B2

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