Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromomethyl 4-methoxyphenyl ketone → 5-Bromo-2-(4-methoxybenzoyl)benzofuran
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromomethyl 4-methoxyphenyl ketone | HCID 4965 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Bromosalicylaldehyde | HCID 72863 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 5-Bromo-2-(4-methoxybenzoyl)benzofuran | HCID 2371724 | 42.6% |
반응 단계
To 150 ml of acetone were suspended 20 g of 5-bromosalicylaldehyde, 22.9 g of 2-bromo-4-methoxyacetophenone and 27.6 g of anhydrous potassium carbonate. After stirring at room temperature for 4 hours, the resulting reaction solution was concentrated to dryness, and then mixed with water to collect precipitated crystals by filtration. After washing with water and subsequent recrystallization from ethanol, 14.02 g of 5-bromo-2-(4-methoxybenzoyl)benzofuran was obtained in the form of colorless prism crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05620991 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-c6128358782945d291fbfe8845ec6610 |
| 출처 메모 | uspto-grants-1997_04 |