Potassium Carbonate → N-(4-fluorobenzyl)-5-(6-methoxyimidazo[1,2-b]pyridazin-2-yl)-2-methylaniline

HRID 539734노트

반응식

HRID 539734 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2=[N:9][C:10]([C:12]3[CH:13]=[CH:14][C:15]([CH3:19])=[C:16]([CH:18]=3)[NH2:17])=[CH:11][N:5]2[N:4]=1.C([O-])([O-])=O.[K+].[K+].[F:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31]Br)=[CH:29][CH:28]=1>C(#N)C>[F:26][C:27]1[CH:34]=[CH:33][C:30]([CH2:31][NH:17][C:16]2[CH:18]=[C:12]([C:10]3[N:9]=[C:6]4[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[N:4][N:5]4[CH:11]=3)[CH:13]=[CH:14][C:15]=2[CH3:19])=[CH:29][CH:28]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 680214-Fluorobenzyl bromideHCID 529038205-(6-Methoxyimidazo[1,2-b]pyridazin-2-yl)-2-methylaniline

생성물 1

HCID 57406703N-(4-fluorobenzyl)-5-(6-methoxyimidazo[1,2-b]pyridazin-2-yl)-2-methylaniline수율 34.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

An 8 mL vial is charged with 5-(6-methoxyimidazo[2,1-f]pyridazin-2-yl)-2-methyl-aniline (20.3 mg, 0.08 mmol) in acetonitrile (0.5 mL), K2CO3 (13 mg) and 4-fluorobenzyl bromide (19 mg, 0.1 mmol). The mixture is stirred for 30 min then filtered, and the filtrate is added into water (10 mL). Solids precipitated and are collected by filtration to give the title compound (10 mg, 34% yield) (compound same as Example 102). LCMS m/z=363.3 [M+H]+, tR=2.57 min.

후처리

  1. filtrationthen filtered
  2. additionthe filtrate is added into water (10 mL)
  3. customSolids precipitated
  4. filtrationare collected by filtration

출처 및 근거

ORD 기록
ord-c7136958642448089aea0666db0ba728
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871767B2

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