Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,4-Diaminobenzonitrile → 2-(Chloromethyl)-1H-benzo[d]imidazole-6-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,4-Diaminobenzonitrile | HCID 737285 | — |
| 반응물 | Ethyl 2-chloroethanecarboximidate hydrochloride | HCID 12470659 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(Chloromethyl)-1H-benzo[d]imidazole-6-carbonitrile | HCID 21844453 | 54.9% |
반응 단계
3.42 g of 3,4-diaminobenzonitrile and 4.06 g of ethyl chloroacetoimidate hydrochloride were dissolved in 100 ml of ethanol, and the solution was refluxed under heating for 3 hours. After cooling and distilling off the solvent, the resulting residue was dissolved in ethyl acetate, washed with water, and then dried. After distilling off the solvent, the crystals thus precipitated were collected by filtration to obtain 2.7 g of 2-chloromethyl-5-benzimidazolecarbonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05620991 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-3d0d18ea8fa64a2b90025bea52f01bed |
| 출처 메모 | uspto-grants-1997_04 |