Methanol → 6-Benzyl-2-oxa-6-azaspiro[3.4]octan-8-amine

HRID 539982노트

반응식

HRID 539982 반응식
[CH2:1]([N:8]1[CH2:15][CH:14]([N+:16]([O-])=O)[C:10]2([CH2:13][O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[NH4+].CO>[Fe].O>[CH2:1]([N:8]1[CH2:15][CH:14]([NH2:16])[C:10]2([CH2:13][O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 3

HCID 887MethanolHCID 25517Ammonium ChlorideHCID 712547596-Benzyl-8-nitro-2-oxa-6-aza-spiro[3.4]octane

생성물 1

HCID 712545836-Benzyl-2-oxa-6-azaspiro[3.4]octan-8-amine

시약·촉매·용매 2

HCID 23925Iron촉매HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

The mixture of 6-benzyl-8-nitro-2-oxa-6-aza-spiro[3.4]octane (2 g, 8.1 mmol), iron powder (2.3 g, 40.5 mmol), ammonium chloride (4.3 g, 81 mmol), methanol (40 mL) and 8 mL of water was heated with stirring for 2 hours at 80° C. The reaction mixture was filtered by a pad of celite. The filtrate was concentrated under reduced pressure, and the residue was used for next step without further purification.

후처리

  1. temperaturewas heated
  2. filtrationThe reaction mixture was filtered by a pad of celite
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customthe residue was used for next step without further purification

출처 및 근거

ORD 기록
ord-b79e12d3f2d847fa9d2aefa188457128
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871756B2

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