1,4-Dioxane → tert-Butyl {trans-1-[6-methyl-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)quinolin-4-yl]-4-hydroxypyrrolidin-3-yl}carboxylate

반응식

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH3:12])[CH:10]=2)[N:5]=[C:4]([N:13]2[CH2:19][C:18]3[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=3[S:16](=[O:24])[CH2:15][CH2:14]2)[CH:3]=1.[OH:25][C@@H:26]1[CH2:30][NH:29][CH2:28][C@H:27]1NC(=O)OC(C)(C)C.C1(P(C2CCCCC2)C2(N(C)C)CC=CC=C2C2C=CC=CC=2)CCCCC1.[CH3:67][C:68]([CH3:71])([O-:70])[CH3:69].[Na+].[O:73]1CCOC[CH2:74]1>>[CH3:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[C:4]([N:13]1[CH2:19][C:18]3[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=3[S:16](=[O:24])[CH2:15][CH2:14]1)[CH:3]=[C:2]2[N:29]1[CH2:30][C@@H:26]([OH:25])[C@H:27]([C:74]([O:70][C:68]([CH3:71])([CH3:69])[CH3:67])=[O:73])[CH2:28]1