2,4-Dichloro-6-methylquinazoline → N-(3-Aminooxetan-3-ylmethyl)-2-chloro-6-methylquinazolin-4-amine
반응식
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:13])[CH:8]=2)[N:3]=1.[NH2:14][CH2:15][C:16]1([NH2:20])[CH2:19][O:18][CH2:17]1>CO>[NH2:20][C:16]1([CH2:15][NH:14][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([CH3:13])[CH:8]=3)[N:3]=[C:2]([Cl:1])[N:11]=2)[CH2:19][O:18][CH2:17]1참가 물질
4
실험 절차
A solution of 2,4-dichloro-6-methylquinazoline (645 mg, 3 mmol) and 3-(aminomethyl)oxetan-3-amine (340 mg, 3.3 mmol) in methanol (15 mL) was stirred at room temperature overnight. After the resulting mixture was concentrated in vacuo, the residue was purified by column chromatography (eluting with 10% methanol in dichloromethane) to afford the desired product.
후처리
- concentrationAfter the resulting mixture was concentrated in vacuo
- customthe residue was purified by column chromatography (eluting with 10% methanol in dichloromethane)
출처 및 근거
- ORD 기록
- ord-463f9b1bff4f4f8cb51f8be1b520ec80
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08871756B2
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