Triethylamine → N-[(3-Aminooxetan-3-yl)methyl]-2-chloroquinazolin-4-amine

HRID 540202노트

반응식

HRID 540202 반응식
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:13][CH2:14][C:15]1([NH2:19])[CH2:18][O:17][CH2:16]1.C(N(CC)CC)C>CO>[NH2:19][C:15]1([CH2:14][NH:13][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]([Cl:1])[N:11]=2)[CH2:18][O:17][CH2:16]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 2528862,4-DichloroquinazolineHCID 217130163-(Aminomethyl)oxetan-3-amine

생성물 1

HCID 86691405N-[(3-Aminooxetan-3-yl)methyl]-2-chloroquinazolin-4-amine수율 92%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2,4-dichloroquinazoline (1.0 g, 5.024 mmol) in methanol (15 mL) was added 3-(aminomethyl)oxetan-3-amine (855 mg, 60%, 5.024 mmol) and triethylamine (101 mg, 1.005 mmol). After being stirred at room temperature overnight, the mixture was concentrated in vacuo. The residue was purified by flash column chromatography to afford 1.2 g of the desired product as a white solid (yield was 92%).

후처리

  1. concentrationthe mixture was concentrated in vacuo
  2. customThe residue was purified by flash column chromatography

출처 및 근거

ORD 기록
ord-ed5f1cc09e1e4dbab5a9729bda253ceb
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871756B2

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