2,3,4,5-Tetrahydrobenzo[f][1,4]thiazepine → HCID 71255080, 화합물

HRID 540290노트

반응식

HRID 540290 반응식
[CH2:1]([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([Br:19])[CH:17]=2)[N:12]=[C:11](Cl)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:21]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[CH2:25][NH:24][CH2:23][CH2:22]1>>[CH2:1]([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([Br:19])[CH:17]=2)[N:12]=[C:11]([N:24]2[CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[S:21][CH2:22][CH2:23]2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 122691062,3,4,5-Tetrahydrobenzo[f][1,4]thiazepineHCID 86691432HCID 86691432, 화합물

생성물 1

HCID 71255080HCID 71255080, 화합물수율 62.7%

반응 조건

온도
80 °C

실험 절차

A mixture of 4-(benzyloxy)-6-bromo-2-chloroquinazoline (700 mg, 2.0 mmol) and 2,3,4,5-tetrahydro-1,4-benzothiazepine (990 mg, 6.0 mmol) was heated at 80° C. for 10 minutes. The resulting reaction mixture was cooled to room temperature and purified by silica gel column chromatography (eluting with dichloromethane) to afford 600 mg of the desired product as a white solid (yield was 62.7%).

후처리

  1. customThe resulting reaction mixture
  2. temperaturewas cooled to room temperature
  3. custompurified by silica gel column chromatography (eluting with dichloromethane)

출처 및 근거

ORD 기록
ord-f6c540c3012b473aa009554a7e57de02
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871756B2

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