Trifluoroacetic acid → 3-Phenylazetidin-3-ol; trifluoroacetic acid

HRID 540389노트

반응식

HRID 540389 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[OH:8][C:9]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]1>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[OH:8][C:9]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:12][NH:11][CH2:10]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 65810524Tert-butyl 3-hydroxy-3-phenylazetidine-1-carboxylate

생성물 1

HCID 669881473-Phenylazetidin-3-ol; trifluoroacetic acid수율 68%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1 ml of trifluoroacetic acid is added to a solution containing 50 mg (0.19 mmol) of tert-butyl 3-hydroxy-3-phenylazetidine-1-carboxylate dissolved in 4 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 3 hours and then concentrated. The crude product obtained is purified by silica gel chromatography (eluent 90/10 dichloromethane/methanol). 36 mg in the form of a white powder are obtained with a yield of 68%.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b86cd5134ced443eaf9959beb2875b9e
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871187B2

반응 노트

불러오는 중…