10-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane → 10-Mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid

HRID 5408노트

반응식

HRID 5408 반응식
[SH:1][CH2:2][CH:3]1[NH:12][C:11](=[O:13])[CH:10]([CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1>C(Cl)Cl>[SH:1][CH2:2][CH:3]1[NH:12][C:11](=[O:13])[CH:10]([CH2:14][C:15]([OH:17])=[O:16])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

참가 물질

3

반응물 1

HCID 1993080710-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane

생성물 1

HCID 1993085410-Mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

10-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane (0.21 g, 0.69 mmol) is dissolved in methylene chloride (15 mL). Gaseous hydrogen chloride is bubbled through the solvent for 15 minutes, and then the reaction is sealed and stirred overnight. The solvent is evaporated the next day to give 10-mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid, MS: M+1=260.

후처리

  1. customGaseous hydrogen chloride is bubbled through the solvent for 15 minutes
  2. customthe reaction is sealed
  3. customThe solvent is evaporated the next day

출처 및 근거

ORD 기록
ord-3ff5ad5cf75d47f1b22289091515d997
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244889

반응 노트

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