Triethylamine → 2-cyclohexyl-1-(methylsulfonyl)-5-nitro-1H-indole

HRID 541072노트

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HRID 541072 반응식
I[C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[NH:11][S:12]([CH3:15])(=[O:14])=[O:13].C(N(CC)CC)C.[C:23]([CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1)#[CH:24].CCOC(C)=O>CN(C=O)C.[Cu]I.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH:25]1([C:23]2[N:11]([S:12]([CH3:15])(=[O:14])=[O:13])[C:3]3[C:2]([CH:24]=2)=[CH:7][C:6]([N+:8]([O-:10])=[O:9])=[CH:5][CH:4]=3)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1

참가 물질

8

반응물 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 70263EthynylcyclohexaneHCID 67284366N-(2-iodo-4-nitrophenyl)methanesulfonamide

생성물 1

HCID 672853302-cyclohexyl-1-(methylsulfonyl)-5-nitro-1H-indole수율 91.9%

시약·촉매·용매 3

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 178418476HCID 178418476, 화합물촉매HCID 6228Dimethylformamide용매

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온도
70 °C

실험 절차

To a mixture containing N-(2-iodo-4-nitrophenyl)methanesulfonamide (13.5 g; 39.5 mmol), triethylamine (17.9 ml; 129 mmol), ethynylcyclohexane (8.55 g; 79 mmol) in DMF (60 ml), CuI (1.5 g; 7.9 mmol) and dichlorobis(triphenylphosphine)palladium(II) [Cl2(PPh3)2Pd] (2.77 g; 3.95 mmol) were added. The reaction mixture was left under stirring at 70° C. for 18 hours. After cooling to room temperature, EtOAc (100 ml) was added, the inorganic precipitate was filtered off and the solution was transferred into a separating funnel and washed with NaHCO3 (saturated solution, 3×200 ml) and water (2×150 ml). The organic phase was dried over Na2SO4, the solvent was removed by evaporation under reduced pressure. The so obtained crude product was crystallized (isopropyl ether) to give 2-cyclohexyl-1-(methylsulfonyl)-5-nitro-1H-indole (11.7 g)

후처리

  1. additionwere added
  2. waitThe reaction mixture was left
  3. temperatureAfter cooling to room temperature
  4. filtrationthe inorganic precipitate was filtered off
  5. customthe solution was transferred into a separating funnel
  6. washwashed with NaHCO3 (saturated solution, 3×200 ml) and water (2×150 ml)
  7. dry with materialThe organic phase was dried over Na2SO4
  8. customthe solvent was removed by evaporation under reduced pressure
  9. customThe so obtained crude product
  10. customwas crystallized (isopropyl ether)

출처 및 근거

ORD 기록
ord-3108c8f787074142b0c3bb1bfc034f23
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871948B2

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