Hydroxylamine → HCID 86645281, 화합물

HRID 541090노트

반응식

HRID 541090 반응식
[Br:1][C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[CH:7][C:6]=2[C:5]([CH:12]=O)=[CH:4][CH:3]=1.[NH2:14][OH:15]>C(O)C>[Br:1][C:2]1[C:11]2[CH:10]=[N:9][CH:8]=[CH:7][C:6]=2[C:5]([CH:12]=[N:14][OH:15])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 787HydroxylamineHCID 58488145HCID 58488145, 화합물

생성물 1

HCID 86645281HCID 86645281, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred solution of 8-bromo-5-isoquinolinecarboxaldehyde (i.e. a product from Step A) (75 mg, 0.3 mmol) in ethanol (7 mL) was added an aqueous solution of hydroxylamine (0.5 mL, 50% in water). After stirring at room temperature overnight, the reaction mixture was concentrated under reduced pressure to provide the title compound as a yellow solid (70 mg).

후처리

  1. concentrationthe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-afefa8806d21460f843355a2456968c0
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871941B2

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